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Invitrogen™ LZTFL1 Polyclonal Antibody
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Catalog No. PIPA561739
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100 μL
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PIPA561739 100 μL
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Catalog No. PIPA561739 Supplier Invitrogen™ Supplier No. PA561739
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: AELGLNEHHQ NEVINYMRFA RSKRGLRLKT VDSCFQDLKE SRLVEDTFTI DEVSEVLNGL QAVVHSEVES ELIN Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 99%.

LZTFL1, also known as Leucine Zipper Transcription Factor-Like 1, is situated on the chromosomal region 3p21.3, which is frequently deleted in various cancers, including kidney cancer. It acts as a tumor suppressor by destabilizing AKT, a key protein in cell growth pathways, thus inhibiting tumor cell growth. Additionally, LZTFL1 has been implicated in the epithelial-mesenchymal transition in COVID-19, suggesting a role in viral response pathways. It is associated with Bardet-Biedl syndrome (BBS) and interacts with IFT27, a regulator of sperm flagellum formation, affecting spermatogenesis and male fertility. Knockout models show a phenotype of obesity, retinal degeneration, and abnormal cilia development, highlighting its role in normal ciliary function. The gene has two transcript isoforms and is part of a transcriptional map covering 250 kb, making it a subject of extensive genetic research.
TRUSTED_SUSTAINABILITY

Specifications

Antigen LZTFL1
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.05 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Lztfl1
Gene Accession No. Q9NQ48
Gene Alias 5530402H04Rik; 6130400H19Rik; AI414725; AW048545; BBS17; fb53f12; leucine zipper transcription factor like 1; leucine zipper transcription factor-like 1; leucine zipper transcription factor-like protein 1; LZTFL1; wu:fb53f12; zgc:56268
Gene Symbols Lztfl1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human LZTFL1. Recombinant protein control fragment (Product #RP-100205).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 54585
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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