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Invitrogen™ M-cadherin Polyclonal Antibody
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Catalog No. PIPA5106546
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100 μL
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PIPA5106546 100 μL
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Catalog No. PIPA5106546 Supplier Invitrogen™ Supplier No. PA5106546
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total CDH15.

Cadherins are a multigene family of Ca++-dependent cell adhesion molecules. They are transmembrane glycoproteins consisting of an extracellular domain, which mediates Ca++-dependent intercellular adhesion by homophilic interactions, a transmembrane region and a cytoplasmic domain. The extracellular domain is divided into a series of subdomains designated EC1-EC5. Homolgies between different members of the cadherin family are most prominent in the cytoplasmic domain and in EC1 and EC2 and much less so in EC5 of the extracellular domain and in the transmembrane region. The binding properties and specificities of the adhesive function are located in the N-terminal part of the molecules. Four members of the cadherin family have been identified and molecularly cloned from mammalian cells. These include the neuronal (N), epithelial (E), placental (P) and muscle (M) cadherins. M-cadherin is not found in fibroblasts but is expressed at low level in myoblasts and is upregulated following induction of myotube formation, suggesting a specific function in skeletal muscle cell differentiation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen M-cadherin
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene CDH15
Gene Accession No. P33146, P55291
Gene Alias AI323380; cadherin 15; cadherin 15, type 1, M-cadherin (myotubule); cadherin-14; Cadherin-15; cadherin-3; Cdh14; Cdh15; CDH3; CDHM; CRSBP-1; HAR; LYVE-1; M cadherin; Mcad; M-cadherin; MRD3; Muscle cadherin; muscle-cadherin; XLKD1
Gene Symbols CDH15
Host Species Rabbit
Immunogen A synthesized peptide derived from human CDH15(Accession P55291), corresponding to amino acid residues D88-L138.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1013, 12555, 361432
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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