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Invitrogen™ M-cadherin Polyclonal Antibody
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Catalog No. PIPA5110758
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100 μL
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PIPA5110758 100 μL
PIPA5111666 100 μL
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Catalog No. PIPA5110758 Supplier Invitrogen™ Supplier No. PA5110758
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: LSIVKALDYE SCEHYELKVS VQNEAPLQAA ALRAERGQAK VRVHVQDTNE PPVFQENPLR TSLAEGAPPG TLVAT Highest antigen sequence indentity to the following orthologs: Rat - 79%, Mouse - 80%.

Cadherins are a multigene family of Ca++-dependent cell adhesion molecules. They are transmembrane glycoproteins consisting of an extracellular domain, which mediates Ca++-dependent intercellular adhesion by homophilic interactions, a transmembrane region and a cytoplasmic domain. The extracellular domain is divided into a series of subdomains designated EC1-EC5. Homolgies between different members of the cadherin family are most prominent in the cytoplasmic domain and in EC1 and EC2 and much less so in EC5 of the extracellular domain and in the transmembrane region. The binding properties and specificities of the adhesive function are located in the N-terminal part of the molecules. Four members of the cadherin family have been identified and molecularly cloned from mammalian cells. These include the neuronal (N), epithelial (E), placental (P) and muscle (M) cadherins. M-cadherin is not found in fibroblasts but is expressed at low level in myoblasts and is upregulated following induction of myotube formation, suggesting a specific function in skeletal muscle cell differentiation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen M-cadherin
Applications Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Concentration 0.10 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene CDH15
Gene Accession No. P55291
Gene Alias AI323380; cadherin 15; cadherin 15, type 1, M-cadherin (myotubule); cadherin-14; Cadherin-15; cadherin-3; Cdh14; Cdh15; CDH3; CDHM; CRSBP-1; HAR; LYVE-1; M cadherin; Mcad; M-cadherin; MRD3; Muscle cadherin; muscle-cadherin; XLKD1
Gene Symbols CDH15
Host Species Rabbit
Immunogen Recombinant Protein corresonding to Human M-cadherin. Recombinant protein control fragment (Product #RP-90195).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1013
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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