Potent and selective TRPM8 channel blocker. Blocks cold- and icilin-induced TRPM8 activation in vitro (IC50 values are 7.8 and 26.9nM respectively). Exhibits no effect at other TRP channels (IC50 > 20µM). Reduces body temperature in vivo.
Chemical Name: N-(2-Aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-2-thiophenecarboxamide hydrochloride
CAS Number: 883976-12-3
Solubility: Soluble to 10mM in water with sonication and to 100mM in DMSO
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