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Tocris™ M8 B hydrochloride

Potent and selective TRPM8 channel blocker

Manufacturer:  Tocris™ 5324/50

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Catalog No. 53-245-0

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For Research Use Only



Potent and selective TRPM8 channel blocker. Blocks cold- and icilin-induced TRPM8 activation in vitro (IC50 values are 7.8 and 26.9nM respectively). Exhibits no effect at other TRP channels (IC50 > 20µM). Reduces body temperature in vivo.
  • Chemical Name: N-(2-Aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-2-thiophenecarboxamide hydrochloride
  • Formula: C22H24N2O3S.HCl
  • CAS Number: 883976-12-3
  • Solubility: Soluble to 10mM in water with sonication and to 100mM in DMSO
  • Purity: >99
Description & Specifications


M8 B hydrochloride
M8 B hydrochloride
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