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Invitrogen™ MA2 Polyclonal Antibody
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Catalog No. PIPA530982
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100 μL
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PIPA530982 100 μL
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Catalog No. PIPA530982 Supplier Invitrogen™ Supplier No. PA530982
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: NT2D1, mouse brain, rat brain. Predicted reactivity: Human (99%), Mouse (83%), Rat (84%), Rhesus Monkey (98%), Bovine (89%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

In patients with cancer, symptoms of limbic and brain-stem dysfunction may result from a para-neoplastic disorder. Two proteins, Ma1 and Ma2, were discovered by presence of autoantibodies against them. Antibodies to Ma1 and Ma2 proteins identify a paraneoplastic disorder that affects the limbic system, brain stem, and cerebellum. These autoantibodies were used to clone Ma2, which codes for a protein (Ma2) that was recognized by serum from the 10 patients, but not by serum from 344 control subjects. Ma2 was selectively expressed by normal brain tissue and by the testicular tumors of the patients. Ma2 shares homology with Ma1, a 'brain-testis-cancer' gene related to other para-neoplastic syndromes and tumors.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MA2
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.75 mg/mL
Conjugate Unconjugated
Formulation 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
Gene PNMA2
Gene Accession No. Q8BHK0, Q9UL42
Gene Alias 40 kDa neuronal protein; A830049P17Rik; KIAA0883; MA2; mKIAA0883; MM2; onconeuronal antigen MA2; Paraneoplastic antigen Ma2; paraneoplastic antigen Ma2 homolog; paraneoplastic Ma antigen 2; paraneoplastic neuronal antigen MM2; Pnma2; retrotransposon gag domain containing 2; RGAG2
Gene Symbols PNMA2
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human PNMA2. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10687, 239157, 305977
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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