Cytiva MabSelect™ Chromatography Media

Description

Protein A affinity medium designed for capturing MAbs from large sample volumes

• High-flow agarose matrix allows for high flow velocities at production scale
• BioProcess medium supported for industrial applications and well-established in approved processes
• Low non-specific binding resulting in low levels of impurities in the product eluate pool
• Oriented coupling of ligand and optimized matrix gives high dynamic binding capacity
• Based on highly cross-linked agarose matrix with recombinant protein A ligand
• Ligand is engineered to favor oriented coupling and expressed in E. coli and is free of components of mammalian origin
• Hydrophilic nature of the base matrix ensures low levels of non-specific

• Average particle size: 85μm (d50V)
• pH Stability cleaning-in-place (CIP): 2 to 12
• pH Stability working range: 3 to 10
• Ligand: recombinant protein A (E.coli)
• Matrix: highly cross-linked agarose
• Binding capacity/mL chromatography medium: ∽30mg human lgG/mL at 2.4 min. residence time
• Pressure/Flow specification: <500cm/hr., <200 kPa, BPG 300, bed height 20cm

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Specifications

• Quantity: 25 mL
• For Use With (Application): For Industrial AppliCatIons and Well-Established in Approved Processes
• Storage Requirements: 2°C to 8°C
• Binding Capacity: 30 mg Human lgG/mL (at 2.4 min. residence time)
• Product Type: MabSelect Media
• Flow Rate: <500 cm/Hoμr
• Particle Size: 85 μm
• Height (English) Bed: 7.87 in.
• Height (Metric) Bed: 20 cm
• Includes: Certificate of Analysis
• Max. Pressure: <200 kPa
• Matrix: Highly Cross-Linked Agarose
• pH Range: 3 to 10
• Ligand Type: Recombinant Protein A (E. coli)