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Invitrogen™ MACC1 Monoclonal Antibody (CL0856)
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Catalog No. PIMA524619
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100 μL
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Catalog No. Quantity
PIMA524619 100 μL
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Catalog No. PIMA524619 Supplier Invitrogen™ Supplier No. MA524619
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Description

Mouse Monoclonal Antibody

Immunogen sequence: FRSGRIAQSM SEANLIDMEA GKLSKSCNIT ECQDPDLLHN WPDAFTLRGN NASKVANPFW NQLSASNPF Highest antigen sequence identity to the following orthologs: Mouse - 57%, Rat - 27%.

MACC1 (Metastasis associated in colon cancer 1) is a key regulator of the hepatocyte growth factor (HGF)-HGF receptor (MET) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. MACC1 protein consists of four domains: ZU5, SH3, and two C-terminal death domains (DD). Expression of MACC1 was found significantly upregulated in malignant tissues (colon cancer of all stages as well as liver and lung metastases) compared to normal tissues or adenomas. MACC1 represents an early and crucial prognostic indicator for colon cancer metastasis that is independent of age, sex, tumor infiltration, nodal status, and lymph vessel invasion. Besides its involvement in signal transduction with the MET receptor, MACC1 also links MET signaling and apoptosis. MACC1 may also be an important therapeutic target for colorectal cancer treatment. At least two isoforms of MACC1 are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MACC1
Applications Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Monoclonal
Clone CL0856
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene MACC1
Gene Accession No. Q6ZN28
Gene Alias 4732474O15Rik; 7A5; Gm267; MACC1; metastasis associated in colon cancer 1; metastasis-associated in colon cancer protein 1; putative binding protein 7a5; RGD1309838; SH3 domain-containing protein 7a5; SH3BP4L
Gene Symbols MACC1
Host Species Mouse
Immunogen Recombinant protein fragment of Human MACC1 (Product #RP-92823)
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 346389
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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