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MACC1 Rabbit anti-Human, Mouse, Polyclonal, Proteintech
SDP

Catalog No. 501733663 Shop All Proteintech Group Inc Products
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50-173-3663 150 μL
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Catalog No. 50-173-3663 Supplier Proteintech Group Inc Supplier No. 219701AP150UL
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Description

Rabbit Polyclonal Antibody

MACC1 (Metastasis associated in colon cancer 1) is a key regulator of the hepatocyte growth factor (HGF)-HGF receptor (MET) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. MACC1 protein consists of four domains: ZU5, SH3, and two C-terminal death domains (DD). Expression of MACC1 was found significantly upregulated in maligt tissues (colon cancer of all stages as well as liver and lung metastases) compared to normal tissues or adenomas. MACC1 represents an early and crucial prognostic indicator for colon cancer metastasis that is independent of age, sex, tumor infiltration, nodal status, and lymph vessel invasion. Besides its involvement in signal transduction with the MET receptor, MACC1 also links MET signaling and apoptosis. MACC1 may also be an important therapeutic target for colorectal cancer treatment. At least two isoforms of MACC1 are known to exist.

Specifications

Antigen MACC1
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.3 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene MACC1
Gene Accession No. Q6ZN28
Gene Alias 7A5, MACC1, SH3BP4L
Gene Symbols MACC1
Host Species Rabbit
Immunogen MACC1 Fusion Protein Ag16884
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 238455, 346389
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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