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Invitrogen™ MACC1 Recombinant Rabbit Monoclonal Antibody (BLR135H)

Rabbit Recombinant Monoclonal Antibody
Supplier: Invitrogen™ MA544457
This item is not returnable.
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Description
Epitope retrieval with citrate buffer pH6.0 is recommended for FFPE cell sections.
MACC1 (Metastasis associated in colon cancer 1) is a key regulator of the hepatocyte growth factor (HGF)-HGF receptor (MET) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. MACC1 protein consists of four domains: ZU5, SH3, and two C-terminal death domains (DD). Expression of MACC1 was found significantly upregulated in malignant tissues (colon cancer of all stages as well as liver and lung metastases) compared to normal tissues or adenomas. MACC1 represents an early and crucial prognostic indicator for colon cancer metastasis that is independent of age, sex, tumor infiltration, nodal status, and lymph vessel invasion. Besides its involvement in signal transduction with the MET receptor, MACC1 also links MET signaling and apoptosis. MACC1 may also be an important therapeutic target for colorectal cancer treatment. At least two isoforms of MACC1 are known to exist.
Specifications
MACC1 | |
Recombinant Monoclonal | |
0.25 mg/mL | |
BBS with 0.1% BSA and 0.09% sodium azide; pH 8.2 | |
Q6ZN28 | |
MACC1 | |
Peptide representing a region between residue 100 and 150 of Human Metastasis-associated in colon cancer protein 1. | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry | |
BLR135H | |
Unconjugated | |
MACC1 | |
4732474O15Rik; 7A5; Gm267; MACC1; metastasis associated in colon cancer 1; metastasis-associated in colon cancer protein 1; putative binding protein 7a5; RGD1309838; SH3 domain-containing protein 7a5; SH3BP4L | |
Rabbit | |
Purified | |
RUO | |
346389 | |
4°C | |
Liquid |
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