Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

Invitrogen™ MACC1 Recombinant Rabbit Monoclonal Antibody (BLR135H)
GREENER_CHOICE

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA544457

 View more versions of this product

Catalog No. PIMA544457


Only null left
Add to Cart
This item is not returnable. View return policy

Description

Description

Epitope retrieval with citrate buffer pH6.0 is recommended for FFPE cell sections.

MACC1 (Metastasis associated in colon cancer 1) is a key regulator of the hepatocyte growth factor (HGF)-HGF receptor (MET) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. MACC1 protein consists of four domains: ZU5, SH3, and two C-terminal death domains (DD). Expression of MACC1 was found significantly upregulated in malignant tissues (colon cancer of all stages as well as liver and lung metastases) compared to normal tissues or adenomas. MACC1 represents an early and crucial prognostic indicator for colon cancer metastasis that is independent of age, sex, tumor infiltration, nodal status, and lymph vessel invasion. Besides its involvement in signal transduction with the MET receptor, MACC1 also links MET signaling and apoptosis. MACC1 may also be an important therapeutic target for colorectal cancer treatment. At least two isoforms of MACC1 are known to exist.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

MACC1
Recombinant Monoclonal
0.25 mg/mL
BBS with 0.1% BSA and 0.09% sodium azide; pH 8.2
Q6ZN28
MACC1
Peptide representing a region between residue 100 and 150 of Human Metastasis-associated in colon cancer protein 1.
100 μL
Primary
Human
Antibody
IgG
Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
BLR135H
Unconjugated
MACC1
4732474O15Rik; 7A5; Gm267; MACC1; metastasis associated in colon cancer 1; metastasis-associated in colon cancer protein 1; putative binding protein 7a5; RGD1309838; SH3 domain-containing protein 7a5; SH3BP4L
Rabbit
Purified
RUO
346389
4°C
Liquid
Product Suggestions

Product Suggestions

Videos
SDS
Documents

Documents

Product Certifications
Promotions

Promotions

Product Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Your feedback has been submitted: Thank you for helping us improve our website.