Macro H2A.2, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA557437

Catalog No. PIPA557437

Description

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation.

Immunogen sequence: ILSSKSLVLG QKLSLTQSDI SHIGSMRVEG IVHPTTAEID LKEDIGKALE KAGGKEFLET VKELRKSQGP LHighest antigen sequence identity to the following orthologs: Mouse - 99%, Rat - 99%.

Specifications

• Antigen: Macro H2A.2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: H2AFY2
• Gene Alias: macroH2A2, core histone macro-H2A.2, core histone macroH2A2.2, histone macroH2A2, mH2A2, H2AFY2
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 361844, 404634, 55506
• Content And Storage: Store at 4°C short term. Store at −20°C long term. Avoid freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
• Concentration: 0.05mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9P0M6, Q8CCK0
• Gene Symbols: H2AFY2
• Immunogen: Recombinant protein corresponding to Human Macro H2A.2
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Research Use Only