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Invitrogen™ MACROD1 Polyclonal Antibody
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Catalog No. PIPA567144
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PIPA567144 100 μL
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Catalog No. PIPA567144 Supplier Invitrogen™ Supplier No. PA567144
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: AEIVLATLREW LEQHKDKVDR LIICVFLEKD EDIYRSRLPH YFPVA Highest antigen sequence identity to the following orthologs - mouse 91%, rat 91%.

Removes ADP-ribose from glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Plays a role in estrogen signaling. Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen. May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation. Could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction. Could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells. Enhances ESR1-mediated transcription activity.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MACROD1
Applications Immunocytochemistry
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene MACROD1
Gene Accession No. Q9BQ69
Gene Alias [Protein ADP-ribosylaspartate] hydrolase MACROD1; [Protein ADP-ribosylglutamate] hydrolase; [Protein ADP-ribosylglutamate] hydrolase MACROD1; ADP-ribose glycohydrolase MACROD1; ADP-ribose glycohydrolase MACROD1; O-acetyl-ADP-ribose deacetylase MACROD1; AI604841; AW743046; D930010J01Rik; LOC613568 protein; Lrp16; MACRO domain containing 1; MACRO domain-containing protein 1; MACROD1; mono-ADP ribosylhydrolase 1; O-acetyl-ADP-ribose deacetylase MACROD1; O-acetyl-ADP-ribose deacetylase MACROD1; LOW QUALITY PROTEIN: O-acetyl-ADP-ribose deacetylase MACROD1; Protein LRP16
Gene Symbols MACROD1
Host Species Rabbit
Immunogen Recombinant Human MACROD1. Recombinant protein control fragment (Product #RP-107790).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 28992
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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