MAdCAM-1 Mouse, anti-Mouse, R718, Clone: MECA-89, BD OptiBuild™

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 751913

Catalog No. BDB751913

Description

The MECA-89 antibody specifically recognizes the mucosal vascular addressin cell adhesion molecule (MAdCAM-1). In the fetus and neonate, MAdCAM-1 is the predominant vascular addressin on the high endothelial venules (HEV) of peripheral lymph nodes. In adult mice, MAdCAM-1 is preferentially expressed in mucosal lymphoid tissues and lamina propria| it is also expressed on sinus-lining cells in the spleen. MAdCAM-1 expression is upregulated on the HEV of peripheral lymph nodes in adult NOD mice and is involved in the development of diabetes and insulitis. Furthermore, there is evidence that IFN-γ can induce MAdCAM-1 expression in non-mucosal sites in adult mice. MAdCAM-1 is a predominant ligand for integrin α4β7, a lymphocyte mucosal homing receptor, and a facultative ligand for CD62L (L-selectin). MECA-89 mAb binds to the second domain of MAdCAM-1 and does not block MAdCAM-1-dependent binding in vitro. Source of the immunogen was endothelial cells from BALB/c mouse mesenteric and peripheral lymph nodes.

Specifications

• Antigen: MAdCAM-1
• Classification: Monoclonal
• Conjugate: R718
• Quantity: 50 μg
• Primary or Secondary: Primary
• Content And Storage: Refrigerate Upon Arrival

• Applications: Flow Cytometry
• Clone: MECA-89
• Host Species: Mouse
• Regulatory Status: RUO
• Target Species: Mouse
• Form: Liquid