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Invitrogen™ MAdCAM1 Monoclonal Antibody (CA102.2C1), eBioscience™
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Catalog No. 5017839
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100 μg
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Catalog No. Quantity
50-178-39 100 μg
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Catalog No. 50-178-39 Supplier Invitrogen™ Supplier No. BMS170
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Description

Mouse Monoclonal Antibody

Description: This antigen is expressed in mucosal lymphoid tissue and lamina propria and is a counter-receptor for CD62L and CD49d. MAdCAM-1 is involved in homing of subpopulation of memory T cells to the gut lamina propria, and recirculation of naive lymphocytes in Peyer's patches and mesenteric lymph nodes. The 1F3F3D4 antibody reacts with mouse tumor necrosis factor-alpha (TNF alpha), a 17 kDa cytokine produced by monocytes, macrophages, neutrophils, NK cells and CD4(+) T cells. Applications Tested: ELISA, Functional Studies (Blocking), Western Blotting.

The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin family and is similar to ICAM1 and VCAM1. At least seven alternatively spliced transcripts encoding different protein isoforms have been found for this gene, but the full-length nature of some variants has not been determined.
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Specifications

Antigen MAdCAM1
Applications ELISA, Functional Assay, Western Blot
Classification Monoclonal
Clone CA102.2C1
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative
Gene MADCAM1
Gene Accession No. Q13477
Gene Alias AV211525; hMAdCAM-1; MACAM1; MADCAM1; MAdCAM-1; mMAdCAM-1; mucosal addressin cell adhesion molecule 1; mucosal addressin cell adhesion molecule-1; mucosal vascular addressin cell adhesion molecule 1; rMAdCAM-1
Gene Symbols MADCAM1
Host Species Mouse
Immunogen Rec. Human MadCAM-1.
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 8174
Target Species Human
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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