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Invitrogen™ MADD Polyclonal Antibody
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Catalog No. PIPA519879
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100 μg
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PIPA519879 100 μg
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Catalog No. PIPA519879 Supplier Invitrogen™ Supplier No. PA519879
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Description

Rabbit Polyclonal Antibody

In Western blot applications, this antibody detects a band at ~200-220kDa. A suggested positive control is Hela cell lysate. PA5-19879 can be used with blocking peptide PEP-0012.

Tumor necrosis factor receptor 1 (TNFR1) contains a death receptor domain that mediates interactions involved in downstream signaling of TNF. A novel protein, MADD (mitogen activated protein (MAP)-kinase activating death domain protein) has recently been shown to associate with the death domain of TNFR1 through its own C-terminal death domain. This interaction is critical for TNFR1 signal generation. Overexpression of MADD activates the MAP (Mitogen Activated Protein) kinases extracellular signal-related kinase (ERK) and c-Jun N-terminal kinase (JNK) and induces the phosphorylation of cytosolic phospholipase A2. This discovery suggests that MADD links tumor necrosis factor TNF and MAP kinase activation and arachidonic acid release. MADD has a 98% homology with another protein, differentially expressed in neoplasmic vs. normal cells (DENN). DENN is a substrate for JNK3, and is important in the hypoxia and stress induced intracellular signalling pathways. MADD also has a 93% sequence conservation with a GDP/GTP exchange protein, Rab3.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MADD
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene MADD
Gene Accession No. O08873, Q80U28, Q8WXG6
Gene Alias 9630059K23Rik; DENN; differentially expressed in normal and neoplastic cells; IG20; Insulinoma glucagonoma clone 20; insulinoma-glucagonoma protein 20; Kiaa0358; Madd; MAP kinase activating death domain; MAP kinase-activating death domain protein; MAP-kinase activating death domain; rab3 GDP/GTP exchange factor; Rab3 GDP/GTP exchange protein; Rab3 GEP; RAB3GEP
Gene Symbols MADD
Host Species Rabbit
Immunogen A peptide corresponding to amino acids near the carboxy terminus of human MADD.
Purification Method Ion-exchange chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 228355, 8567, 94193
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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