Invitrogen™ MAEL Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5115533

Catalog No. PIPA5115533

Description

Antibody detects endogenous levels of total Mael.

The mammalian homolog of the Drosophila protein Maelstrom is expressed in the male germline and localizes to the sex body in spermatocytes and the chromatid body in round spermatids. Similar to its expression in Drosophila, Maelstrom is a component of nuages, a germ-cell specific organelle and is thought to be essential for spermatogenesis and transposon repression during meiosis. In humans, Maelstrom has been found to be expressed only in the testis and in various cancer cell lines. Treatment of these cell lines with the demethylating agent 5'-Aza-2-Deoxycytidine significantly upregulated Maelstrom levels, indicating that its expression is regulated by DNA methylation.

Specifications

• Antigen: MAEL
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MAEL
• Gene Alias: 4933405K18Rik; AU019877; cancer/testis antigen 128; CT128; MAEL; maelstrom homolog; maelstrom homolog (Drosophila); maelstrom spermatogenic transposon silencer; protein maelstrom homolog; RGD1309333; RP11-102C16.1; SPATA35; spermatogenesis associated 35; testicular tissue protein Li 116
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 84944
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide
• Gene Accession No.: Q96JY0
• Gene Symbols: MAEL
• Immunogen: A synthesized peptide derived from human MAEL(Accession Q96JY0), corresponding to amino acid residues G390-S434.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG