MAGE 1 Antibody (MA454), Alexa Fluor™ 532, Novus Biologicals™

Mouse Monoclonal Antibody

Supplier:  Novus Biologicals NBP233094AF532

Catalog No. NP233094A32

Description

MAGE 1 Monoclonal specifically detects MAGE 1 in Human, Rat, Canine samples. It is validated for ELISA.

Specifications

• Antigen: MAGE 1
• Classification: Monoclonal
• Conjugate: Alexa Fluor 532
• Formulation: 50 mM sodium borate with 0.05% sodium azide
• Gene Symbols: MAGEA1
• Immunogen: Recombinant full-length human MAGE 1 protein (Uniprot: P43355)
• Quantity: 0.1 mL
• Primary or Secondary: Primary
• Test Specificity: Recognizes a protein of 42-46kDa, identified as MAGE-1. This monoclonal antibody does not cross-react with MAGE-2, -3, -4, -6 -9, -10, -or -12 protein. Human malignant neoplasms carry rejection antigens that are recognized by the patients' autologous, tumor directed and specific, cytolytic, CD8+ T lymphocyte clones (CTL). The MAGE family of genes codes an important group of antigens. It was identified that melanomas and primary glial brain tumors express common melanoma associated antigens (MAAs). Because MAGE-1 is expressed on a significant proportion of human neoplasms of various histological types (melanoma, brain tumors of glial origin, neuroblastoma, non-small cell lung cancer, breast, gastric, colorectal, ovarian, renal cell carcinomas) and not on normal tissues, the encoded antigen may serve as a marker of early detection and target for cancer immunotherapy.
• Content And Storage: Store at 4°C in the dark.

• Applications: ELISA
• Clone: MA454
• Dilution: ELISA
• Gene Alias: Antigen MZ2-E, Cancer/testis antigen 1.1, cancer/testis antigen family 1, member 1, CT1.1melanoma antigen family A 1, MAGE-1 antigen, MAGE1A, MAGE1melanoma antigen MAGE-1, melanoma antigen family A, 1 (directs expression of antigen MZ2-E), melanoma-associated antigen 1, melanoma-associated antigen MZ2-E, MGC9326
• Host Species: Mouse
• Purification Method: Protein A or G purified
• Research Discipline: Apoptosis, Cancer, Melanoma Cell Markers, Tumor Suppressors
• Gene ID (Entrez): 4100.0
• Target Species: Human, Rat, Canine
• Isotype: IgG1 κ