MAGE 1 Mouse anti-Human, Rat, Canine, Alexa Fluor 532, Clone: MA454, Novus Biologicals
Mouse Monoclonal Antibody
Manufacturer: Novus Biologicals NBP233094AF532
DescriptionMAGE 1 Monoclonal antibody specifically detects MAGE 1 in Human, Rat, Canine samples. It is validated for ELISA.
|Human MAGE-A1 full length recombinant protein|
|Protein G purified|
|Apoptosis, Cancer, Melanoma Cell Markers, Tumor Suppressors|
|Canine, Human, Rat|
|Alexa Fluor™ 532|
|50 mM sodium borate with 0.05% sodium azide|
|Antigen MZ2-E, Cancer/testis antigen 1.1, cancer/testis antigen family 1, member 1, CT1.1melanoma antigen family A 1, MAGE-1 antigen, MAGE1A, MAGE1melanoma antigen MAGE-1, melanoma antigen family A, 1 (directs expression of antigen MZ2-E), melanoma-associated antigen 1, melanoma-associated antigen MZ2-E, MGC9326|
|Store at 4°C in the dark.|
|Recognizes a protein of 42-46kDa, identified as MAGE-1. This MAb does not cross-react with MAGE-2, -3, -4, -6 -9, -10, -or -12 protein. Human malignant neoplasms carry rejection antigens that are recognized by the patients′ autologous, tumor directed and specific, cytolytic, CD8+ T lymphocyte clones (CTL). The MAGE family of genes codes an important group of antigens. It was identified that melanomas and primary glial brain tumors express common melanoma associated antigens (MAAs). Because MAGE-1 is expressed on a significant proportion of human neoplasms of various histological types (melanoma, brain tumors of glial origin, neuroblastoma, non-small cell lung cancer, breast, gastric, colorectal, ovarian, renal cell carcinomas) and not on normal tissues, the encoded antigen may serve as a marker of early detection and target for cancer immunotherapy.|
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