Invitrogen™ MAGEC2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA537071

Catalog No. PIPA537071

Description

This antibody detects endogenous protein at a molecular weight of 41 kDa. Purity is >95% by SDS-PAGE.

MAGE-C2/C3 (Melanoma-associated antigen C2, Hepatocellular carcinoma-associated antigen 587) is a 373 amino acid protein encoded by the human gene MAGEC2. Genes of the MAGE family direct the expression of tumor antigens that are recognized on human melanomas by autologous cytolytic T lymphocytes. Among tumor tissues, MAGE-C2/C3 is frequently expressed in seminomas, melanomas, and bladder transitional cell carcinomas. It is also expressed in a significant fraction of head and neck carcinomas, breast carcinomas, nonsmall-cell lung carcinomas, and sarcomas. In hepatocellular carcinoma, there is a inverse correlation between tumor differentiation and protein expression, i. e. the lower the differentiation, the higher percentage of expression. MAGE-C2/C3 is not expressed in normal tissues, except in germ cells in the seminiferous tubules and in Purkinje cells of the cerebellum. It is strongly expressed in spermatogonia and primary spermatocytes, however, at later stages of maturation, expression gradually decreases to become undetectable in mature spermatids.

Specifications

• Antigen: MAGEC2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MAGEC2
• Gene Alias: Cancer/testis antigen 10; CT10; HCA587; hepatocellular cancer antigen 587; hepatocellular carcinoma-associated antigen 587; MAGE family member C2; MAGEC2; MAGE-C2; MAGE-C2 antigen; MAGEE1; MAGE-E1 antigen; melanoma antigen family C, 2; melanoma antigen family C2; melanoma antigen, family E, 1, cancer/testis specific; melanoma-associated antigen C2; uncharacterized protein LOC317590
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 317590, 51438
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9UBF1
• Gene Symbols: MAGEC2
• Immunogen: Synthetic peptide corresponding to amino acids 237-282 of human MAGEC2.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov