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Invitrogen™ MAGEC2 Polyclonal Antibody
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Catalog No. PIPA537071
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100 μL
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PIPA537071 100 μL
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Catalog No. PIPA537071 Supplier Invitrogen™ Supplier No. PA537071
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Description

Rabbit Polyclonal Antibody

This antibody detects endogenous protein at a molecular weight of 41 kDa. Purity is >95% by SDS-PAGE.

MAGE-C2/C3 (Melanoma-associated antigen C2, Hepatocellular carcinoma-associated antigen 587) is a 373 amino acid protein encoded by the human gene MAGEC2. Genes of the MAGE family direct the expression of tumor antigens that are recognized on human melanomas by autologous cytolytic T lymphocytes. Among tumor tissues, MAGE-C2/C3 is frequently expressed in seminomas, melanomas, and bladder transitional cell carcinomas. It is also expressed in a significant fraction of head and neck carcinomas, breast carcinomas, nonsmall-cell lung carcinomas, and sarcomas. In hepatocellular carcinoma, there is a inverse correlation between tumor differentiation and protein expression, i. e. the lower the differentiation, the higher percentage of expression. MAGE-C2/C3 is not expressed in normal tissues, except in germ cells in the seminiferous tubules and in Purkinje cells of the cerebellum. It is strongly expressed in spermatogonia and primary spermatocytes, however, at later stages of maturation, expression gradually decreases to become undetectable in mature spermatids.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MAGEC2
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
Gene MAGEC2
Gene Accession No. Q9UBF1
Gene Alias Cancer/testis antigen 10; CT10; HCA587; hepatocellular cancer antigen 587; hepatocellular carcinoma-associated antigen 587; MAGE family member C2; MAGEC2; MAGE-C2; MAGE-C2 antigen; MAGEE1; MAGE-E1 antigen; melanoma antigen family C, 2; melanoma antigen family C2; melanoma antigen, family E, 1, cancer/testis specific; melanoma-associated antigen C2; uncharacterized protein LOC317590
Gene Symbols MAGEC2
Host Species Rabbit
Immunogen Synthetic peptide corresponding to amino acids 237-282 of human MAGEC2.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 317590, 51438
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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