Invitrogen™ MAN1B1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5104494

Catalog No. PIPA5104494

Description

Antibody detects endogenous levels of total MAN1B1.

Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man9GlcNAc2 to produce Man8GlcNAc2, but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man5-6GlcNAc2. Tremblay L.O., Glycobiology 9:1073-1078(1999) [PubMed: 10521544]. Gonzalez D.S., J. Biol. Chem. 274:21375-21386(1999) [PubMed: 10409699]. Clark H.F., Genome Res. 13:2265-2270(2003) [PubMed: 12975309].

Specifications

• Antigen: MAN1B1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MAN1B1
• Gene Alias: 3.2.1.113; E430019H13Rik; endoplasmic Reticulum Class I alpha-mannosidase; endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase; endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase 1; ER alpha 1,2-mannosidase; ER alpha-1,2-mannosidase; ER mannosidase 1; ERMan1; ERManI; Gm108; MAN1B1; Man9GlcNAc2-specific processing alpha-mannosidase; man9GlcNAc2-specific-processing alpha-mannosidase; MANA-ER; Mannosidase alpha class 1B member 1; mannosidase, alpha, class 1B, member 1; MRT15; RGD1563595; RP11-350O14.2; UNQ747/PRO1477
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 11253, 227619, 499751
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: A2AJ15, B2GUY0, Q9UKM7
• Gene Symbols: MAN1B1
• Immunogen: A synthesized peptide derived from human MAN1B1(Accession Q9UKM7), corresponding to amino acid residues V135-A185.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov