Invitrogen™ MAN2B2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5113537

Catalog No. PIPA5113537

Description

MAN2B2 Polyclonal Antibody for Western Blot, IHC (P), ELISA

The MAN2B2 (Mannosidase Alpha Class 2B Member 2) gene encodes an enzyme that is involved in the processing and modification of glycoproteins by hydrolyzing alpha-mannosidic linkages. Located on chromosome 4, the MAN2B2 protein is crucial for proper lysosomal function and is part of the glycosyl hydrolase family. Pathogenic variants in the MAN2B2 gene have been linked to a rare congenital disorder of glycosylation (CDG), known as MAN2B2-CDG, characterized by immune deficiency, developmental delay, stroke, and dysmorphic facial features. These mutations lead to an altered mannosylation profile, impacting glycoprotein processing and cellular functions. Studies have shown that reintroducing wild-type MAN2B2 can restore the normal mannosylation profile in patient cells, highlighting its therapeutic potential. Furthermore, recent research has identified circular RNA from this gene (circMAN2B2) that is implicated in the proliferation of hepatocellular carcinoma cells, suggesting a role in cancer biology.

Specifications

• Antigen: MAN2B2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MAN2B2
• Gene Alias: 135 kD alpha-D-mannosidase; 135 kDa alpha-D-mannosidase; Ab2-450; core-specific lysosomal alpha-1,6-Mannosidase; epididymis-specific alpha-mannosidase; HMG17L3; Kiaa0935; Man2b2; mannosidase 2, alpha B2; mannosidase alpha class 2B member 2; mannosidase, alpha, class 2B, member 2; mKIAA0935; NHC
• Host Species: Rabbit
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 23324
• Content And Storage: -20°C or -80°C if preferred
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1.84 mg/mL
• Formulation: PBS with 50% glycerol and 0.03% ProClin 300; pH 7.4
• Gene Accession No.: Q9Y2E5
• Gene Symbols: MAN2B2
• Immunogen: Recombinant Human Epididymis-specific alpha-mannosidase protein (347-523AA).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG