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Invitrogen™ MAP1 Polyclonal Antibody
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Catalog No. PIPA519995
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100 μg
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PIPA519995 100 μg
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Catalog No. PIPA519995 Supplier Invitrogen™ Supplier No. PA519995
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Description

Rabbit Polyclonal Antibody

A suggested positive control is EL4 cell lysate. PA5-19995 can be used with blocking peptide PEP-0117.

Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Members of the Bcl-2 family are known to be critical regulators of this process. These proteins are characterized by the presence of several conserved motifs termed Bcl-2 homology (BH) domains. A related protein termed MAP-1 has recently been identified. This protein contains a BH3-like domain and induces caspase-dependent apoptosis in mammalian cells when overexpressed. It forms homodimers and associates with Bcl-2 family members such as Bax, Bcl-2, and Bcl-XL in vitro and in vivo. It has been suggested that MAP-1 associates with the tumor suppressor RASSF1A following death receptor activation, allowing a conformational change in Bax that leads to cellular apoptosis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MAP1
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene MOAP1
Gene Accession No. Q96BY2, Q9ERH6
Gene Alias AA987038; MAP1; Map-1; Moap1; Modulator of apoptosis 1; paraneoplastic antigen like 4; paraneoplastic antigen Ma4; paraneoplastic Ma antigen family member 4; PNMA4
Gene Symbols MOAP1
Host Species Rabbit
Immunogen A 15 amino acid peptide from near the center of human MAP-1.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 64112, 64113
Target Species Human, Mouse
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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