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MAP2K2 Mouse anti-Canine, Human, Mouse, Rat, Clone: OTI1A2, liquid, TrueMAB™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

Manufacturer:  OriGeneSupplier Diversity Partner TA505680S

Catalog No. 50-167-6116


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Description

Description

MEK1 (Mitogen activated protein kinase kinase 1) catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. MEK1 activates ERK1 and ERK2 MAP kinases. Mitogen activated protein kinase kinase 2 (MEK2 or MAPKK2) is a member of a family of tyrosine/threonine protein kinases that activate the ERK1 and 2 and MAPK enzymes by phosphorylating both residues within the threonine/glutamate/tyrosine (TEY) motif in the activation loop. MEK1 and 2 are also activated by dual phosphorylation, which occurs on serine 218 and 222, in the activation loop of the MEK. Threonine 292 of MEK1 is phosphorylated by ERK 2, which serves as a negative feedback loop by suppressing activation of MEK1.
Specifications

Specifications

MAP2K2
Monoclonal
Unconjugated
MAP2K2
Liquid
MAP2K2
Full length human recombit protein of human MAP2K2 produced in HEK293T cell.
Affinity Chromatography
RUO
Antibody
Monoclonal
Canine, Human, Mouse, Rat
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
OTI1A2
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
P36506, P36507, Q63932
CFC4, MAPKK2, MEK2, MKK2, PRKMK2
Mouse
IgG2a
30 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
26396, 5605, 58960, 611939
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