MAP2K2 Mouse anti-Human, Clone: OTI8G6, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF500471

Catalog No. 50-165-9541

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

MEK1 (Mitogen activated protein kinase kinase 1) catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. MEK1 activates ERK1 and ERK2 MAP kinases. Mitogen activated protein kinase kinase 2 (MEK2 or MAPKK2) is a member of a family of tyrosine/threonine protein kinases that activate the ERK1 and 2 and MAPK enzymes by phosphorylating both residues within the threonine/glutamate/tyrosine (TEY) motif in the activation loop. MEK1 and 2 are also activated by dual phosphorylation, which occurs on serine 218 and 222, in the activation loop of the MEK. Threonine 292 of MEK1 is phosphorylated by ERK 2, which serves as a negative feedback loop by suppressing activation of MEK1.

Specifications

• Antigen: MAP2K2
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: MAP2K2
• Gene Alias: CFC4, MAPKK2, MEK2, MKK2, PRKMK2
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 5605
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI8G6
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: P36507
• Gene Symbols: MAP2K2
• Immunogen: Full-length protein expressed in 293T cell transfected with human MAP2K2 expression vector
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1