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MAP2K2 Mouse anti-Human, Clone: OTI8G6, lyophilized, TrueMAB™

Mouse Monoclonal Antibody
Supplier: OriGene CF500471

Description
Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO
MEK1 (Mitogen activated protein kinase kinase 1) catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. MEK1 activates ERK1 and ERK2 MAP kinases. Mitogen activated protein kinase kinase 2 (MEK2 or MAPKK2) is a member of a family of tyrosine/threonine protein kinases that activate the ERK1 and 2 and MAPK enzymes by phosphorylating both residues within the threonine/glutamate/tyrosine (TEY) motif in the activation loop. MEK1 and 2 are also activated by dual phosphorylation, which occurs on serine 218 and 222, in the activation loop of the MEK. Threonine 292 of MEK1 is phosphorylated by ERK 2, which serves as a negative feedback loop by suppressing activation of MEK1.Specifications
MAP2K2 | |
Monoclonal | |
Unconjugated | |
MAP2K2 | |
CFC4, MAPKK2, MEK2, MKK2, PRKMK2 | |
Mouse | |
Affinity Chromatography | |
RUO | |
5605 | |
-20° C, Avoid Freeze/Thaw Cycles | |
Lyophilized |
Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot | |
OTI8G6 | |
PBS with 8% trehalose and no preservative; pH 7.3 | |
P36507 | |
MAP2K2 | |
Full-length protein expressed in 293T cell transfected with human MAP2K2 expression vector | |
100 μg | |
Primary | |
Human | |
Antibody | |
IgG1 |
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