Invitrogen™ MAP2K4 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5120296

Catalog No. PIPA5120296

Description

Positive test controls include: SH-SY5Y, BT-474, MCF-7, mouse thymus, mouse liver, rat liver. The target is usually found in the following locations: Cytoplasm, Nucleus. Immunogen sequence: LATGRFPYPK WNSVFDQLTQ VVKGDPPQLS NSEEREFSPS FINFVNLCLT KDESKRPKYK ELLKHPFILM YEERAVEVAC YVCKILDQMP ATPSSPMYVD.

MAP2K4 (MEK4) serine/threonine kinase (mitogen-activated protein kinase 4) MEK4 or MKK4 is a dual specificity kinase of the STE7 family that phosphorylates and activates JNK1 and -2 as well as p38. MAP2K4 preferentially phosphorylates the tyrosine residue of JNKs. MAP2K4 mediates a variety of physiological and pathophysiological processes such as responses to cellular stresses and inflammatory cytokines. MAP2K4 is important for carcinogenesis; a loss-off-function mutation in MAP2K4 was found in lung and pancreatic tumors. Conversely, a pro-oncogenic role was also found for MAP2K4.

Specifications

• Antigen: MAP2K4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MAP2K4
• Gene Alias: C-JUN N-terminal kinase kinase 1; dual specificity mitogen-activated protein kinase kinase 2; dual specificity mitogen-activated protein kinase kinase 4; dual specificity mitogen-activated protein kinase kinase 4; dual specificity mitogen-activated protein kinase kinase 4a; JNK kinase 1; JNK-activated kinase 1; JNK-activating kinase 1; JNKK; JNKK 1; JNKK1; MAP kinase activator 2; MAP kinase kinase 4; Map2k4; map2k4.L; map2k4a; map2k4-a; map2k4-b; MAP2K4delta; MAPK/ERK kinase 4; MAPKK 4; MAPKK4; MEK 4; MEK4; mitogen activated protein kinase kinase 4; mitogen activated protein kinase kinase 4, variant 1; mitogen-activated protein kinase kinase 4; mitogen-activated protein kinase kinase 4 L homeolog; mitogen-activated protein kinase kinase 4a; MKK4; mkk4a; MKK4A-l; PRKMK4; SAPK kinase 1; SAPK/ERK kinase 1; SAPK/Erk/kinase 1; SAPKK1; SAPKK-1; Sek1; Serk1; Skk1; Stress-activated protein kinase kinase 1; XELAEV_18044157mg; XMEK2; zgc:136500; zMKK4 protein
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 26398, 287398, 6416
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1.92 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P45985, P47809
• Gene Symbols: MAP2K4
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 300-399 of human MAP2K4 (NP_003001.1).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov