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Invitrogen™ MAP4K2 Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA543202
Description
Peptide sequence: TVTSELAAVK IVKLDPGDDI SSLQQEITIL RECRHPNVVA YIGSYLRNDR Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rat: 100%; Zebrafish: 86%.
MAP4K2 (GCK) is a serine/ threonine protein kinase that activates the JNK pathway. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of the germinal center, where it may participate in B-cell differentiation. The kinase may also play a role in the regulation of vesicle targeting or fusion. The protein encoded by MAP4K2 is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1.
Specifications
MAP4K2 | |
Polyclonal | |
Unconjugated | |
MAP4K2 | |
AI385662; B lymphocyte serine/threonine protein kinase; B lymphocyte serine/threonine-protein kinase; BL44; dZ150L22.2; GC kinase; GCK; germinal center kinase; germinal centre kinase (GC kinase); LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase kinase 2; MAP4K2; map4k2l; map4k2l-2; map4k3l; MAPK/ERK kinase kinase kinase 2; MEK kinase kinase 2; MEKKK 2; mitogen activated protein kinase kinase kinase kinase 2; mitogen-activated protein kinase kinase kinase kinase 2; mitogen-activated protein kinase kinase kinase kinase 2-like; mitogen-activated protein kinase kinase kinase kinase 3-like; Rab8 interacting protein; rab8-interacting protein; Rab8ip; si:dz150l22.2; si:dz263j20.1; Unknown (protein for MGC:136670); zgc:136670 | |
Rabbit | |
Affinity Chromatography | |
RUO | |
5871 | |
-20°C, Avoid Freeze/Thaw Cycles | |
Liquid |
Western Blot | |
0.5 mg/mL | |
PBS with 2% sucrose and 0.09% sodium azide | |
Q12851 | |
MAP4K2 | |
Synthetic peptide directed towards the N-terminal of human MAP4K2 (aa 36-85). | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
Safety and Handling
WARNING: Cancer - www.P65Warnings.ca.gov
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