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Description
This gene encodes a member of the Ste20 family of serine/threonine protein kinases. The protein belongs to the subfamily that consists of members, such as germinal center kinase (GCK), that are characterized by an N-terminal catalytic domain and C-terminal regulatory domain. The kinase activity of the encoded protein can be stimulated by UV radiation and tumor necrosis factor-alpha. The protein specifically activates the c-Jun N-terminal kinase (JNK) signaling pathway. Evidence suggests that it functions upstream of mitogen-activated protein kinase kinase kinase 1 (MEKK1). This gene previously was referred to as RAB8-interacting protein-like 1 (RAB8IPL1), but it has been renamed mitogen-activated protein kinase kinase kinase kinase 3 (MAP4K3). [provided by RefSeq]
Specifications
Specifications
| Antigen | MAP4K3 |
| Applications | Immunohistochemistry (PFA fixed), Western Blot |
| Classification | Monoclonal |
| Clone | 219CT8.3.1 |
| Conjugate | Unconjugated |
| Description | Mouse monoclonal antibody raised against human MAP4K3. |
| Dilution | Immunohistochemistry (1:100) Western Blot (1:100-1:500) The optimal working dilution should be determined by the end user. |
| Formulation | In PBS (0.09% sodium azide) |
| Gene Alias | GLK/MAPKKKK3/RAB8IPL1 |
| Gene Symbols | MAP4K3 |
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