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Invitrogen™ MAP4K3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA550275

Catalog No. PA550275


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Description

Description

The antibody detects endogenous levels of total MAP4K3 protein.

MAP4K3 (also known as GLK) is a member of the STE20 family of serine/threonine protein kinases and contains N-terminal catalytic domain and C-terminal regulatory domain. MAP4K3 is upstream of the MEKK1 target and is stimulated by UV radiation and TNF-alpha and can lead to the activation of the JNK signaling pathway. MAP4K3 can directly activate PKC-T, during TCR signaling and people with systemic lupus erythematosus show considerable enhanced MAP4K3 expression and activation of PKC-T, and the kinase IKK in T cells. MAP4K3 can act as a pro-apoptotic kinase which orchestrates activation of BAX via the concerted posttranscriptional modulation of PUMA, BAD, and BIM. The kinase activity of the encoded protein can be stimulated by UV radiation and tumor necrosis factor-alpha. The protein specifically activates the c-Jun N-terminal kinase (JNK) signaling pathway. Evidence suggests that it functions upstream of mitogen-activated protein kinase kinase 1 (MEKK1). MAP4K3 previously was referred to as RAB8-interacting protein-like 1 (RAB8IPL1), but it has been renamed mitogen-activated protein kinase kinase kinase 3 (MAP4K3).
TRUSTED_SUSTAINABILITY
Specifications

Specifications

MAP4K3
Polyclonal
Unconjugated
MAP4K3
4833416M01Rik; 4833416M07Rik; 9530052P13Rik; germinal center kinase-like kinase; germinal center kinase-related protein kinase; GLK; MAP4K3; MAPK/ERK kinase kinase kinase 3; MAPKKKK3; MEK kinase kinase 3; MEKKK 3; MEKKK3; mitogen activated protein kinase kinase kinase kinase 3; mitogen-activated protein kinase kinase kinase kinase 3; RAB8IPL1
Rabbit
Antigen affinity chromatography
RUO
225028, 8491
-20°C
Liquid
Immunohistochemistry (Paraffin), Western Blot
1.3 mg/mL
PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
Q8IVH8, Q99JP0
MAP4K3
Fusion protein corresponding to a region derived from internal residues of human Mitogen-activated protein kinase kinase kinase kinase 3.
100 μL
Primary
Human, Mouse
Antibody
IgG
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