MAPK8IP1 Monoclonal Antibody (OTI3A12), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA809896

Catalog No. 50-168-3084

Description

The protein encoded by this gene is a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes.

Specifications

• Antigen: MAPK8IP1
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: MAPK8IP1
• Gene Alias: IB1, JIP-1, JIP1, PRKM8IP
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 9479
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Clone: OTI3A12
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: Q9UQF2
• Gene Symbols: MAPK8IP1
• Immunogen: Full length human recombit protein of human MAPK8IP1 produced in HEK293T cell.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2b