MAPK8IP1 Rabbit anti-Human, Polyclonal, Bioss

Catalog No.	Quantity
50-198-7158	100 μL

Catalog No. 50-198-7158 Supplier Bioss Supplier No. BS6255R

Description

Rabbit Polyclonal Antibody

The protein encoded by this gene is a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes.

Specifications

• Antigen: MAPK8IP1
• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene: MAPK8IP1
• Gene Accession No.: Q9UQF2
• Gene Alias: C-Jun-amino-terminal kinase-interacting protein 1; Ib1; IB-1; Islet-brain 1; Islet-brain-1; Jip1; JIP-1; JIP-1-related protein; JNK MAP kinase scaffold protein 1; JNK-interacting protein 1; JRP; Mapk8ip; MAPK8IP1; mitogen activated protein kinase 8 interacting protein; mitogen activated protein kinase 8 interacting protein 1; mitogen-activated protein kinase 8 interacting protein 1; Mitogen-activated protein kinase 8-interacting protein 1; mjip-2a; PRKM8 interacting protein; Prkm8ip; protein kinase, mitogen-activated 8 interacting protein; Skip
• Gene Symbols: MAPK8IP1
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic peptide derived from human JIP1/MAPK8IP1.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 9479
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG