Invitrogen™ MAPKAPK3 Monoclonal Antibody (01)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA529410

Catalog No. PIMA529410

Description

This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%). This antibody has specificity for Human MAPKAPK3/MK3.

MAPKAPK3 functions as an integrative element of signaling in both mitogen and stress responses. MAPKAPK3 functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. MAPKAPK3 was shown to be activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses. MAPKAPK3 was reported to interact with, phosphorylate and repress the activity of E47, which is a basic helix-loop-helix transcription factor known to be involved in the regulation of tissue-specific gene expression and cell differentiation.

Specifications

• Antigen: MAPKAPK3
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with no preservative
• Gene Accession No.: Q16644
• Gene Symbols: MAPKAPK3
• Immunogen: Recombinant Human MAPKAPK3/MK3 Protein (Met1-Gln382).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a

• Applications: Immunohistochemistry (Paraffin)
• Clone: 01
• Conjugate: Unconjugated
• Gene: MAPKAPK3
• Gene Alias: 3PK; AI874665; chromosome 3p kinase; MAP kinase-activated protein kinase 3; MAPK-activated protein kinase 3; MAPKAP kinase 3; MAPKAP3; MAPKAPK3; MAPKAP-K3; MAPKAPK-3; MapkKapk3; mitogen activated protein kinase-activated protein kinase 3; mitogen-activated protein kinase-activated protein kinase 3; MK3; MK-3; OTTHUMP00000210806; OTTHUMP00000210807
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 7867
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid