Invitrogen™ MAPKAPK3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5115542

Catalog No. PIPA5115542

Description

Antibody detects endogenous levels of total MAPK3.

MAPKAPK3 functions as an integrative element of signaling in both mitogen and stress responses. MAPKAPK3 functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. MAPKAPK3 was shown to be activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses. MAPKAPK3 was reported to interact with, phosphorylate and repress the activity of E47, which is a basic helix-loop-helix transcription factor known to be involved in the regulation of tissue-specific gene expression and cell differentiation.

Specifications

• Antigen: MAPKAPK3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MAPKAPK3
• Gene Alias: 3PK; AI874665; chromosome 3p kinase; MAP kinase-activated protein kinase 3; MAPK-activated protein kinase 3; MAPKAP kinase 3; MAPKAP3; MAPKAPK3; MAPKAP-K3; MAPKAPK-3; MapkKapk3; mitogen activated protein kinase-activated protein kinase 3; mitogen-activated protein kinase-activated protein kinase 3; MK3; MK-3; OTTHUMP00000210806; OTTHUMP00000210807
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 102626, 315994, 7867
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide
• Gene Accession No.: Q16644, Q3UMW7, Q66H84
• Gene Symbols: MAPKAPK3
• Immunogen: A synthesized peptide derived from human MAPKAPK3(Accession Q16644), corresponding to amino acid residues M299-V349.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG