Invitrogen™ MARCH4 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA553149

Catalog No. PIPA553149

Description

Immunogen sequence: WKVLNYDKTK DLEDQKAGGR TNPRTSSSTQ ANIPSSEEET AGTPAPEQGP AQAAGHPSGP LSHHHCAYTI LHILSHLRPH EQRSP Highest antigen sequence identity to the following orthologs: Mouse - 79%, Rat - 78%.

RNF174 (MARCH4) is a multi-pass membrane protein mainly found in the membrane of Golgi apparatus. It is a complex enzyme with a RING-CH-type zinc finger. It acts as a ubiquitin-protein ligase mainly involved in third step of ubiquitin conjugation. The RINGv-type zinc finger domain is required for E3 ligase activity in which the E3 ubiquitin-protein ligase mediates ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. It is mainly expressed in brain and placenta.

Specifications

• Antigen: MARCH4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MARCH4
• Gene Alias: BC056494; E3 ubiquitin-protein ligase MARCH4; Kiaa1399; MARCH4; MARCHF4; MARCH-IV; membrane associated ring finger 4; membrane associated ring-CH-type finger 4; membrane-associated ring finger (C3HC4) 4; membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase; membrane-associated RING finger protein 4; Membrane-associated RING-CH protein IV; mKIAA1399; RING finger protein 174; RING-type E3 ubiquitin transferase MARCH4; RNF174
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 57574
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9P2E8
• Gene Symbols: MARCH4
• Immunogen: Recombinant protein corresponding to Human MARCH4. Recombinant protein control fragment (Product #RP-90983).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG