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Invitrogen™ MARCH8 Polyclonal Antibody
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Catalog No. PIPA588893
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100 μL
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PIPA588893 100 μL
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Catalog No. PIPA588893 Supplier Invitrogen™ Supplier No. PA588893
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: YNRVIYVQNC PETSKKNIFE KSPLTEPNFE NKHGYGICHS DTNSSCCTEP EDTGAEIIHV; Positive Samples: 22Rv1, U-87MG, Mouse testis, Rat testis, Rat liver; Cellular Location: Cytoplasmic vesicle membrane, Early endosome membrane, Lysosome membrane, Multi-pass membrane protein.

MARCH8 (c-MIR) is a novel E3 ubiquitin ligase designated as the modulator of immune recognition (MIR) family, whose catalytic domain is a variant RING domain (RING-CH domain). MARCH8 was found as a functional and structural homolog of KSHV MIR1 and MIR2. MARCH8 targets B7-2 to lysosomal degradation and down-regulates the B7-2 surface expression through ubiquitination of its cytoplasmic tail. Furthermore, MARCH8 has been shown to down-regulate the expression of transferrin receptor and Fas, an important molecule for the induction of apoptosis. MARCH8 is the first example of an E3 ubiquitin ligase that is capable of inhibiting MHC II expression. Recent findings suggest that MARCH8 may regulate immune responses by promoting ubiquitination of MHC-II and CD86, leading to their subsequent endocytosis and lysosomal degradation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MARCH8
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 3 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene MARCH8
Gene Accession No. Q5T0T0, Q9DBD2
Gene Alias 1300017E09Rik; cellular modulator of immune recognition; cellular modulator of immune recognition (c-MIR); CMIR; c-MIR; c-mir, cellular modulator of immune recognition; E3 ubiquitin-protein ligase MARCH8; E3 ubiquitin-protein ligase MARCHF8; E3 ubiquitin-protein ligase MARCH8; March8; MARCHF8; MARCH-VIII; membrane associated ring finger 8; membrane associated ring-CH-type finger 8; membrane-associated ring finger (C3HC4) 8; membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase; membrane-associated RING finger protein 8; Membrane-associated RING-CH protein VIII; MIR; RING finger protein 178; RING-type E3 ubiquitin transferase MARCH8; RING-type E3 ubiquitin transferase MARCHF8; RNF178; RP11-67C2.1
Gene Symbols MARCH8
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 232-291 of human MARCH8 (NP_6594582).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 220972, 312656, 71779
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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