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MARCH8 Rabbit anti-Human, Mouse, Polyclonal, Proteintech
SDP

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group Inc 141191AP150UL

Encompass_Preferred

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Catalog No. 50-172-9224


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Description

Description

MARCH8 (c-MIR) is a novel E3 ubiquitin ligase designated as the modulator of immune recognition (MIR) family, whose catalytic domain is a variant RING domain (RING-CH domain). MARCH8 was found as a functional and structural homolog of KSHV MIR1 and MIR2. MARCH8 targets B7-2 to lysosomal degradation and down-regulates the B7-2 surface expression through ubiquitination of its cytoplasmic tail. Furthermore, MARCH8 has been shown to down-regulate the expression of transferrin receptor and Fas, an important molecule for the induction of apoptosis. MARCH8 is the first example of an E3 ubiquitin ligase that is capable of inhibiting MHC II expression. Recent findings suggest that MARCH8 may regulate immune responses by promoting ubiquitination of MHC-II and CD86, leading to their subsequent endocytosis and lysosomal degradation.
Specifications

Specifications

MARCH8
Polyclonal
Unconjugated
MARCH8
c MIR, MARCH VIII, MARCH8, MIR, RING finger protein 178, RNF178
Rabbit
Antigen Affinity Chromatography
RUO
220972, 71779
-20°C
Liquid
Immunoprecipitation, Western Blot
0.13 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q5T0T0, Q9DBD2
MARCH8
MARCH8 Fusion Protein Ag5268
150 μL
Primary
Human, Mouse
Antibody
IgG
SDS
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