MARCH8 Rabbit anti-Human, Polyclonal, Bioss

Catalog No.	Quantity
50-198-9000	100 μL

Catalog No. 50-198-9000 Supplier Bioss Supplier No. BS9342R

Description

Rabbit Polyclonal Antibody

MARCH8 (c-MIR) is a novel E3 ubiquitin ligase designated as the modulator of immune recognition (MIR) family, whose catalytic domain is a variant RING domain (RING-CH domain). MARCH8 was found as a functional and structural homolog of KSHV MIR1 and MIR2. MARCH8 targets B7-2 to lysosomal degradation and down-regulates the B7-2 surface expression through ubiquitination of its cytoplasmic tail. Furthermore, MARCH8 has been shown to down-regulate the expression of transferrin receptor and Fas, an important molecule for the induction of apoptosis. MARCH8 is the first example of an E3 ubiquitin ligase that is capable of inhibiting MHC II expression. Recent findings suggest that MARCH8 may regulate immune responses by promoting ubiquitination of MHC-II and CD86, leading to their subsequent endocytosis and lysosomal degradation.

Specifications

• Antigen: MARCH8
• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene: 43898
• Gene Accession No.: Q5T0T0
• Gene Alias: 1300017E09Rik; BOS_24287; Cellular modulator of immune recognition; cellular modulator of immune recognition (c-MIR); CMIR; c-MIR; c-mir, cellular modulator of immune recognition; E3 ubiquitin-protein ligase MARCH8; E3 ubiquitin-protein ligase MARCH8-like; LOC100341456; March8; MARCH-VIII; membrane associated ring finger 8; membrane associated ring-CH-type finger 8; membrane-associated ring finger (C3HC4) 8; membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase; Membrane-associated RING finger protein 8; Membrane-associated RING-CH protein VIII; Mir; RING finger protein 178; RING-type E3 ubiquitin transferase MARCH8; RNF178; RP11-67C2.1
• Gene Symbols: 43898
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic peptide derived from human MARCH8.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 220972
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG