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  6. Invitrogen™ MARCO Monoclonal Antibody (PLK-1), APC, eBioscience™, Invitrogen™ 

Invitrogen™ MARCO Monoclonal Antibody (PLK-1), APC, eBioscience™, Invitrogen™

Catalog No. 17544741
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17-544-741 25 Tests
17-544-742 100 Tests
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Catalog No. 17-544-741 Supplier Invitrogen™ Supplier No. 17544741
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Description

Mouse Monoclonal Antibody

Description: This PLK-1 monoclonal antibody recognizes human MARCO also known as SR-A6 or SCARA2. Applications Reported: This PLK-1 antibody has been reported for use in flow cytometric analysis. Applications Tested: This PLK-1 antibody has been pre-diluted and tested by flow cytometric analysis of human monocyte-derived macrophages. This may be used at 5 μL (0.06 μg) per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser

MARCO, also known as SR-A6 or SCARA2, is a macrophage surface receptor and a member of the class A scavenger receptor family. As a part of the innate antimicrobial immune system, MARCO can bind both Gram-negative and Gram-positive bacteria via an extracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. In addition to short cytoplasmic and transmembrane domains, there is an extracellular spacer domain and a long, extracellular collagenous domain. The protein may form a trimeric molecule by the association of the collagenous domains of three identical polypeptide chains. Due to its expression in tumor infiltrating macrophages, and its role in inhibiting immune responses within tumor environment, MARCO has been indicated as a potential target for cancer immunotherapy.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MARCO
Applications Flow Cytometry
Classification Monoclonal
Clone PLK-1
Concentration 5 μL/Test
Conjugate APC
Formulation PBS with BSA and 0.09% sodium azide; pH 7.2
Gene Marco
Gene Accession No. Q9UEW3
Gene Alias AI323439; Ly112; macrophage receptor MARCO; Macrophage receptor with collagenous structure; MARCO; SCARA2; Scavenger receptor class A member 2; scavenger receptor class A, member 2; SR-A6
Gene Symbols Marco
Host Species Mouse
Immunogen Human alveolar macrophages.
Purification Method Affinity chromatography
Quantity 25 Tests
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 8685
Target Species Human
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Isotype IgG3
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Safety and Handling

WARNING: Cancer and Reproductive Harm - www.P65Warnings.ca.gov
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