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Invitrogen™ MARK1 Polyclonal Antibody
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Catalog No. PIPA5110728
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100 μL
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PIPA5110728 100 μL
PIPA5110740 100 μL
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Catalog No. PIPA5110728 Supplier Invitrogen™ Supplier No. PA5110728
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: QEEEELKPYT EPDPDFNDTK RIDIMVTMGF ARDEINDALI NQKYDEVMAT YILLGRKPPE FEGGESLSSG NLCQRSRPSS DLNNSTLQSP AHLKVQRSIS ANQKQRRFSD HAGPSIPPAV SYTKRPQANS VESEQK Highest antigen sequence indentity to the following orthologs: Mouse - 93%, Rat - 94%.

MARK1 (MARK) is a serine/threonine kinase which is involved in cytoskeletal organization and biogenesis. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. MARK1 is involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).
TRUSTED_SUSTAINABILITY

Specifications

Antigen MARK1
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene MARK1
Gene Accession No. Q9P0L2
Gene Alias AW491150; B930025N23Rik; ELKL motif serine/threonine-protein kinase 3; ELKL motif serine-threonine protein kinase 3; Emk3; KIAA1477; MAP/microtubule affinity regulating kinase 1; MAP/microtubule affinity-regulating kinase 1; MARK; MARK1; mark1 {ECO:0000312; microtubule affinity regulating kinase 1; mKIAA1477; mPar-1c; PAR1 homolog c; Par1c; Par-1c; RGD:619882}; serine/threonine-protein kinase MARK1
Gene Symbols MARK1
Host Species Rabbit
Immunogen Recombinant Protein corresonding to Human MARK1. Recombinant protein control fragment (Product #RP-89778).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4139
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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