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Invitrogen™ MARK1 Polyclonal Antibody
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Catalog No. PIPA532914
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50 μg
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PIPA532914 50 μg
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Catalog No. PIPA532914 Supplier Invitrogen™ Supplier No. PA532914
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Description

Rabbit Polyclonal Antibody

Percent identity with other species by BLAST analysis: Human, Gibbon, Monkey, Marmoset, Dog, Bat, Bovine, Panda, Rabbit, Opossum (100%); Elephant, Horse, Lizard (94%); Rat, Turkey, Chicken, Platypus (89%). For IHC(P), use heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

MARK1 (MARK) is a serine/threonine kinase which is involved in cytoskeletal organization and biogenesis. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. MARK1 is involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).
TRUSTED_SUSTAINABILITY

Specifications

Antigen MARK1
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.75 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% sodium azide
Gene MARK1
Gene Accession No. Q9P0L2
Gene Alias AW491150; B930025N23Rik; ELKL motif serine/threonine-protein kinase 3; ELKL motif serine-threonine protein kinase 3; Emk3; KIAA1477; MAP/microtubule affinity regulating kinase 1; MAP/microtubule affinity-regulating kinase 1; MARK; MARK1; mark1 {ECO:0000312; microtubule affinity regulating kinase 1; mKIAA1477; mPar-1c; PAR1 homolog c; Par1c; Par-1c; RGD:619882}; serine/threonine-protein kinase MARK1
Gene Symbols MARK1
Host Species Rabbit
Immunogen Synthetic 18 amino acid peptide from N-terminus of human MARK1.
Purification Method Antigen affinity chromatography
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100339168, 4139, 478965, 539563
Target Species Human, Canine, Rabbit, Monkey, Bovine, Bat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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