Invitrogen™ MARK1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA532914

Catalog No. PIPA532914

Description

Percent identity with other species by BLAST analysis: Human, Gibbon, Monkey, Marmoset, Dog, Bat, Bovine, Panda, Rabbit, Opossum (100%); Elephant, Horse, Lizard (94%); Rat, Turkey, Chicken, Platypus (89%). For IHC(P), use heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

MARK1 (MARK) is a serine/threonine kinase which is involved in cytoskeletal organization and biogenesis. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. MARK1 is involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).

Specifications

• Antigen: MARK1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MARK1
• Gene Alias: AW491150; B930025N23Rik; ELKL motif serine/threonine-protein kinase 3; ELKL motif serine-threonine protein kinase 3; Emk3; KIAA1477; MAP/microtubule affinity regulating kinase 1; MAP/microtubule affinity-regulating kinase 1; MARK; MARK1; mark1 {ECO:0000312; microtubule affinity regulating kinase 1; mKIAA1477; mPar-1c; PAR1 homolog c; Par1c; Par-1c; RGD:619882}; serine/threonine-protein kinase MARK1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 100339168, 4139, 478965, 539563
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.75 mg/mL
• Formulation: PBS with 0.1% sodium azide
• Gene Accession No.: Q9P0L2
• Gene Symbols: MARK1
• Immunogen: Synthetic 18 amino acid peptide from N-terminus of human MARK1.
• Quantity: 50 μg
• Primary or Secondary: Primary
• Target Species: Human, Canine, Rabbit, Monkey, Bovine, Bat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov