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Invitrogen™ MARVELD2 Polyclonal Antibody
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Catalog No. PIPA597168
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100 μL
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PIPA597168 100 μL
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Catalog No. PIPA597168 Supplier Invitrogen™ Supplier No. PA597168
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: ELLLGAGVFA CVTAYIHKDS EWYNLFGYSQ PYGMGGVGGL GSMYGGYYYT GPKTPFVLVV AGLAWITTII ILVLGMSMYY RTILLDSNWW PLTEFGINVA L; Positive Samples: SH-SY5Y; Cellular Location: Cell junction, Cell membrane, Multi-pass membrane protein, tight junction.

Tight junctions form an important barrier of paracellular transport in epithelial cells. Sealing of two adjacent cells at bicellular tight junctions, a point where three adjacent cells are in contact with each other. Tricellulin is the first protein identified that specifically concentrates in tricellular tight junctions. This protein has four membrane spanning domains, similarly to claudins. Tricellulin expression is high in epithelium-derived tissues, such as small intestine, kidney and lung. Functional evidence for the role of tricellulin in tight junction formation comes from siRNA studies, where suppression of its expression leads to compromised epithelial barrier and tight junction formation. Loss of function in tricellulin mutants missing all or most of a conserved region in the cytosolic domain which binds to the cytosolic scaffolding protein ZO-1, indicate that interaction with other known tight junction proteins plays an important role for the function of tricellulin.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MARVELD2
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.51 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene MARVELD2
Gene Accession No. Q3UZP0, Q8N4S9
Gene Alias BC003296; DFNB49; MARVD2; MARVEL (membrane-associating) domain containing 2; MARVEL domain containing 2; MARVEL domain-containing protein 2; Marveld2; Mrvldc2; Tric; Trica; Tricb; Tricc; Tricellulin
Gene Symbols MARVELD2
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence within amino acids 200-300 of human MARVELD2 (NP_0010336922).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 153562, 218518, 365657
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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