Invitrogen™ MASP2 Monoclonal Antibody (c5), Invitrogen™

Catalog No.	Quantity
PIMA543665	100 μL
PIMA543666	20 μL

Catalog No. PIMA543665

Supplier: Invitrogen™ MA543665

Description

Mouse Monoclonal Antibody

Mannose (or mannan)-binding lectin (MBL), also known as serum mannosebinding protein (MBP), initiates the lectin branch of the innate immune response by binding to the surface of potentially pathogenic microorganisms and initiating complement fixation through an N-terminal collagen-like domain. MBL is a key component in immune response in that it can directly trigger neutralization of invading microorganisms by an Ab-independent mechanism. Mutations of human MBL are associated with immunodeficiency resulting from a reduction in the ability of the mutant MBL to initiate complement fixation. In human, three types of MBL-associated serine proteases, MASP-1, MASP-2 and MASP-3, and a truncated form of MASP-2 (small MBL-associated protein; sMAP or MAp19) complex with MBL to activate the lectin pathway of the complement system. Activated MASPs subsequently cleave and activate downstream components of the complement pathway. MASP-3 is an alternatively spliced product from the MASP-1 gene and may function to inhibit MASP-2 by competing for MBL binding and inhibiting the activation of MBLassociated MASP-2.

Specifications

• Antigen: MASP2
• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Classification: Monoclonal
• Clone: C9
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.4
• Gene: MASP2
• Gene Accession No.: O00187
• Gene Alias: mannan binding lectin serine peptidase 2; mannan-binding; mannan-binding lectin serine peptidase 1 pseudogene 1; mannan-binding lectin serine peptidase 2; mannan-binding lectin serine peptidase 2 variant 1; mannan-binding lectin serine peptidase 2 variant 2; mannan-binding lectin serine peptidase 2 variant 3; mannan-binding lectin serine peptidase 2 variant 4; mannan-binding lectin serine protease 1 pseudogene 1; mannan-binding lectin serine protease 2; Mannan-binding lectin serine protease 2 A chain; Mannan-binding lectin serine protease 2 B chain; mannose binding lectin-associated serine protease-2; mannose-binding protein-associated serine protease 2; MAp19; MASP1P1; Masp2; MASP-2; MBL-associated plasma protein of 19 kD; MBL-associated serine protease 2; sb:eu714; small MBL-associated protein; sMAP; wu:fb62a09
• Gene Symbols: MASP2
• Host Species: Mouse
• Immunogen: Recombinant Human Mannose Associated Serine Protease 2 (MASP2), Thr280-Val433 (Accession O00187), with N-terminal His Tag.
• Purification Method: Protein A/G
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 10747
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2b κ

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov