MASP2 Polyclonal Antibody, Invitrogen™

Catalog No.	Quantity
PIPA556111	100 μL

Catalog No. PIPA556111 Supplier Thermo Scientific Supplier No. PA556111

Description

Rabbit Polyclonal Antibody

Immunogen sequence: PVCEPVCGLS ARTTGGRIYG GQKAKPGDFP WQVLILGGTT AAGALLYDNW VLTAAHAVYE QKHDASALDI RMGTLKRLSP HYTQAWSEAV FIHEGYTHDA GFDNDIALIK LNNKVVINSN ITPICLPRKE AESFMRTDDI GTASGWGL Highest antigen sequence identity to the following orthologs: Mouse - 78%, Rat - 78%.

Mannose (or mannan)-binding lectin (MBL), also known as serum mannosebinding protein (MBP), initiates the lectin branch of the innate immune response by binding to the surface of potentially pathogenic microorganisms and initiating complement fixation through an N-terminal collagen-like domain. MBL is a key component in immune response in that it can directly trigger neutralization of invading microorganisms by an Ab-independent mechanism. Mutations of human MBL are associated with immunodeficiency resulting from a reduction in the ability of the mutant MBL to initiate complement fixation. In human, three types of MBL-associated serine proteases, MASP-1, MASP-2 and MASP-3, and a truncated form of MASP-2 (small MBL-associated protein; sMAP or MAp19) complex with MBL to activate the lectin pathway of the complement system. Activated MASPs subsequently cleave and activate downstream components of the complement pathway. MASP-3 is an alternatively spliced product from the MASP-1 gene and may function to inhibit MASP-2 by competing for MBL binding and inhibiting the activation of MBLassociated MASP-2.

Specifications

• Antigen: MASP2
• Applications: Western Blot
• Classification: Polyclonal
• Concentration: 0.1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene: MASP2
• Gene Accession No.: O00187
• Gene Alias: mannan binding lectin serine peptidase 2; mannan-binding; mannan-binding lectin serine peptidase 1 pseudogene 1; mannan-binding lectin serine peptidase 2; mannan-binding lectin serine peptidase 2 variant 1; mannan-binding lectin serine peptidase 2 variant 2; mannan-binding lectin serine peptidase 2 variant 3; mannan-binding lectin serine peptidase 2 variant 4; mannan-binding lectin serine protease 1 pseudogene 1; mannan-binding lectin serine protease 2; Mannan-binding lectin serine protease 2 A chain; Mannan-binding lectin serine protease 2 B chain; mannose binding lectin-associated serine protease-2; mannose-binding protein-associated serine protease 2; MAp19; MASP1P1; Masp2; MASP-2; MBL-associated plasma protein of 19 kD; MBL-associated serine protease 2; sb:eu714; small MBL-associated protein; sMAP; wu:fb62a09
• Gene Symbols: MASP2
• Host Species: Rabbit
• Immunogen: Recombinant protein corresponding to Human MASP2
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 10747
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Research Use Only