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Invitrogen™ Mast Cell Chymase Polyclonal Antibody
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Catalog No. PIPA596382
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100 μL
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PIPA596382 100 μL
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Catalog No. PIPA596382 Supplier Invitrogen™ Supplier No. PA596382
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Description

Rabbit Polyclonal Antibody

Positive Samples: A-549, A-431, HT-29, MCF7, Mouse lung, Mouse small intestine; Cellular Location: Cytoplasmic granule Immunogen sequence: ITEEEDTWQK LEVIKQFRHP KYNTSTLHHD IMLLKLKEKA SLTLAVGTLP FPSQFNFVPP GRMCRVAGWG RTGVLKPGSD TLQEVKLRLM DPQACSHFRD FDHNLQLCVG NPRKTKSAFK GDSGGPLLCA GVAQGIVSYG RSDAKPPAVF TRISHYRPWI NQILQAN.

This gene product is a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Angiotensin II has been implicated in blood pressure control and in the pathogenesis of hypertension, cardiac hypertrophy, and heart failure. Thus, this gene product is a target for cardiovascular disease therapies. This gene maps to 14q11. 2 in a cluster of genes encoding other proteases.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Mast Cell Chymase
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.51 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene CMA1
Gene Accession No. P21844, P23946
Gene Alias alpha-chymase; Chymase; chymase 1; chymase 1 preproprotein transcript E; chymase 1 preproprotein transcript I; chymase 1, mast cell; chymase, heart; chymase, mast cell; CMA1; CYH; CYM; mast cell; Mast cell chymase 1; mast cell protease 3; Mast cell protease 5; mast cell protease I; Mast cell protease III; MCP3P; Mcp5; Mcp-5; Mcpt3; Mcpt5; MCT1; mMCP-5; rMCP-3; rMCP-5; rMCP-III
Gene Symbols CMA1
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 81-247 of human Mast Cell Chymase (CMA1) (NP_0018271).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1215, 17228
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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