Invitrogen™ Mast Cell Chymase Recombinant Rabbit Monoclonal Antibody (JB74-32)

Catalog No.	Quantity
PIMA534663	100 μL

Catalog No. PIMA534663

Supplier: Invitrogen™ MA534663

Description

Rabbit Recombinant Monoclonal Antibody

Positive Control: Rat spleen and mouse spleen tissue lysates, Human tonsil tissue, human skin tissue.

This gene product is a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Angiotensin II has been implicated in blood pressure control and in the pathogenesis of hypertension, cardiac hypertrophy, and heart failure. Thus, this gene product is a target for cardiovascular disease therapies. This gene maps to 14q11. 2 in a cluster of genes encoding other proteases.

Specifications

• Antigen: Mast Cell Chymase
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Classification: Recombinant Monoclonal
• Clone: JB74-32
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: TBS with 0.05% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
• Gene: CMA1
• Gene Accession No.: P23946
• Gene Alias: alpha-chymase; Chymase; chymase 1; chymase 1 preproprotein transcript E; chymase 1 preproprotein transcript I; chymase 1, mast cell; chymase, heart; chymase, mast cell; CMA1; CYH; CYM; mast cell; Mast cell chymase 1; mast cell protease 3; Mast cell protease 5; mast cell protease I; Mast cell protease III; MCP3P; Mcp5; Mcp-5; Mcpt3; Mcpt5; MCT1; mMCP-5; rMCP-3; rMCP-5; rMCP-III
• Gene Symbols: CMA1
• Host Species: Rabbit
• Immunogen: Synthetic peptide within Human Mast Cell Chymase aa 198-247.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 1215
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles, store in dark
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG