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Invitrogen™ Mast Cell Chymase Recombinant Rabbit Monoclonal Antibody (JB74-32)
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Catalog No. PIMA534663
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PIMA534663 100 μL
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Catalog No. PIMA534663 Supplier Invitrogen™ Supplier No. MA534663
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Description

Rabbit Recombinant Monoclonal Antibody

Positive Control: Rat spleen and mouse spleen tissue lysates, Human tonsil tissue, human skin tissue.

This gene product is a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Angiotensin II has been implicated in blood pressure control and in the pathogenesis of hypertension, cardiac hypertrophy, and heart failure. Thus, this gene product is a target for cardiovascular disease therapies. This gene maps to 14q11. 2 in a cluster of genes encoding other proteases.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Mast Cell Chymase
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Recombinant Monoclonal
Clone JB74-32
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation TBS with 0.05% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
Gene CMA1
Gene Accession No. P23946
Gene Alias alpha-chymase; Chymase; chymase 1; chymase 1 preproprotein transcript E; chymase 1 preproprotein transcript I; chymase 1, mast cell; chymase, heart; chymase, mast cell; CMA1; CYH; CYM; mast cell; Mast cell chymase 1; mast cell protease 3; Mast cell protease 5; mast cell protease I; Mast cell protease III; MCP3P; Mcp5; Mcp-5; Mcpt3; Mcpt5; MCT1; mMCP-5; rMCP-3; rMCP-5; rMCP-III
Gene Symbols CMA1
Host Species Rabbit
Immunogen Synthetic peptide within Human Mast Cell Chymase aa 198-247.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1215
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles, store in dark
Product Type Antibody
Form Liquid
Isotype IgG
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