Invitrogen™ MAST2 Polyclonal Antibody

Catalog No.	Quantity
PIPA558900	100 μL

Catalog No. PIPA558900 Supplier Invitrogen™ Supplier No. PA558900

Description

Rabbit Polyclonal Antibody

Immunogen sequence: GESGEEDPFP SRDPRSLGPM VPSLLTGITL GPPRMESPSG PHRRLGSPQA IEEAASSSSA GPNLGQSG Highest antigen sequence identity to the following orthologs: Mouse - 46%, Rat - 46%.

Syntrophin is an adapter protein that functions to bind certain signaling molecules to the dystrophin-associated protein complex. This complex connects the extracellular matrix to the intracellular cytoskeleton for construction and maintenance of the postsynaptic structures in the neuromuscular junction and the central nervous system. Microtubule-associated serine/threonine-protein kinase 2 (MAST205) is a testis-specific, cytoplasmic protein that functions in a multi-protein complex in the maturation of spermatids. MAST205 is involved in linking the dystrophin/utrophin network with microtubule filaments via Syntrophin. By forming a complex with TRAF6, MAST205 regulates lipopolysaccharide-induced IL-12 synthesis in macrophages. This leads to the inhibition of TRAF6 NF-kappa-B activation. Two isoforms exist for MAST205 due to alternative splicing. Isoform 1 represents the full length protein, while isoform 2 lacks the residues 327-396 and 1091-1113. The N-terminus of MAST205 must be phosphorylated in order for ubiquitination to occur at the same site. This ubiquitination leads to the degradation of MAST205 via proteasome-mediated proteolysis.

Specifications

• Antigen: MAST2
• Applications: Immunohistochemistry (Paraffin)
• Classification: Polyclonal
• Concentration: 0.4 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene: MAST2
• Gene Accession No.: Q6P0Q8
• Gene Alias: KIAA0807; Mast2; MAST205; microtubule associated serine/threonine kinase 2; microtubule associated testis specific serine/threonine protein kinase; microtubule-associated serine/threonine-protein kinase 2; Mtssk
• Gene Symbols: MAST2
• Host Species: Rabbit
• Immunogen: Recombinant protein corresponding to Human MAST2. Recombinant protein control fragment (Product #RP-98307).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 23139
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov