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MASTL Polyclonal Antibody, Bethyl Laboratories

Catalog No. 501572450
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50-157-2450 10 μL
50-157-2449 100 μL
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Catalog No. 50-157-2450 Supplier Bethyl Laboratories, Inc Supplier No. IHC00638T
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt.

Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintece. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at ′Ser-62′ and ′Ser-67′, respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation. Ota T., Nat. Genet. 36:40-45(2004). Deloukas P., Nature 429:375-381(2004). Beausoleil S.A., Nat. Biotechnol. 24:1285-1292(2006).

Specifications

Antigen MASTL
Applications Immunohistochemistry
Classification Polyclonal
Conjugate Unconjugated
Formulation TBS with 0.1% BSA and 0.09% sodium azide
Gene MASTL
Gene Accession No. Q96GX5
Gene Alias GREATWALL, GW, GWL, MAST-L, RP11-85G18.2, THC2, hGWL, greatwall protein kinase, microtubule-associated serine/threonine-protein kinase-like, serine/threonine-protein kinase greatwall
Gene Symbols MASTL
Host Species Rabbit
Immunogen Between 550 and 600
Purification Method Antigen affinity chromatography
Quantity 10 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 84930
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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