Invitrogen™ ATOH1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA593035

Catalog No. PIPA593035

Description

Immunogen sequence: LQTPSGGEQP PPPPASCKSD HHHLRTAASY EGGAGNATAA GAQQASGGSQ RPTPPGSCRT RFSAPASAGG YSVQLDALHF STFEDSALTA MMAQKNLSPS LPGSILQPVQ EENSKTSPRS HRSDGEFSPH SHYSDSDEAS; Positive Samples: SW620, HepG2, human pacenta, Mouse liver, Mouse heart; Cellular Location: Nucleus.

The Drosophila atonal gene produces a protein with basic helix loop helix (bHLH) domains that plays an essential role in the development of the Drosophila nervous system. Mammalian atonal homolog 1 (MATH-1) is a helix-loop-helix (HLH) transcription factor that is structurally homologous to the product of the Drosophila proneural gene atonal. MATH-1, so known as Atoh1, Ath1 or HATH-1, is a 351 amino acid protein with an atonal-related basic HLH domain. In mice, expression of MATH-1 takes place by embryonic day 9. 5 and initially localizes to the cranial ganglions and the dorsal part of the central nervous system. Prominent expression of MATH-1 is in the dorsal part of the central nervous system but becomes restricted to the external granular layer of the cerebellum by day 18 and is undetectable in the adult nervous system. It is suggested that MATH-1 may play a role in the differentiation of subsets of neural cells by activating E box-dependent transcription.

Specifications

• Antigen: ATOH1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Atoh1
• Gene Alias: ATH1; Atoh1; atonal bHLH transcription factor 1; atonal homolog 1; atonal homolog 1 (Drosophila); atonal homolog bHLH transcription factor 1; BHLHA14; Class A basic helix-loop-helix protein 14; H MATH-1; Hath1; Helix-loop-helix protein hATH-1; helix-loop-helix protein mATH-1; Math1; MATH-1; Protein atonal homolog 1; RGD1565171
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 11921, 474
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.84 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P48985, Q92858
• Gene Symbols: Atoh1
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 215-354 of human ATOH1 (NP_0051631).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov