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Invitrogen™ Matuzumab Chimeric Recombinant Rabbit Monoclonal Antibody (Matuzumab)
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Catalog No. PIMA547998
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200 μg
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Catalog No. Quantity
PIMA547998 200 μg
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Catalog No. PIMA547998 Supplier Invitrogen™ Supplier No. MA547998
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Description

Rabbit Recombinant Monoclonal Antibody

Specificity: This antibody binds the extracellular domain III of the human EGFR and does not cross react with murine EGFR. It was also reported that residues S460/G461 in EGFR domain III are essential components of the epitope. This antibody binds at a site distinct from the EGF binding site, preventing conformational re-arrangement required for dimerization, a process essential for high-affinitiy ligand binding. This antibody can only recognize the active form of EGFR. The antibody binds to both glyco- and aglyco receptor forms.

Matuzumab is a humanized monoclonal antibody used in cancer treatment. It has a high affinity for EGFR, frequently associated with the growth of blood vessels in malignancy, facilitating tumor growth and survival.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Matuzumab Chimeric
Applications ELISA, Flow Cytometry, Functional Assay, Inhibition Assays, Western Blot, Immunocytochemistry
Classification Recombinant Monoclonal
Clone Matuzumab
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% ProClin 300
Gene Cd8b1
Gene Accession No. P10300
Gene Alias EMD-72000; H425
Host Species Rabbit
Immunogen Domain III of the extracellular domain of human EGRF.
Purification Method Protein A
Quantity 200 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12526
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG κ
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