Invitrogen™ Matuzumab Recombinant Human Monoclonal Antibody (Matuzumab)

Human Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA547997

Catalog No. PIMA547997

Description

Specificity: This antibody binds the extracellular domain III of the human EGFR and does not cross react with murine EGFR. It was also reported that residues S460/G461 in EGFR domain III are essential components of the epitope. This antibody binds at a site distinct from the EGF binding site, preventing conformational re-arrangement required for dimerization, a process essential for high-affinitiy ligand binding. This antibody can only recognize the active form of EGFR. The antibody binds to both glyco- and aglyco receptor forms.

Matuzumab is a humanized monoclonal antibody used in cancer treatment. It has a high affinity for EGFR, frequently associated with the growth of blood vessels in malignancy, facilitating tumor growth and survival.

Specifications

• Antigen: Matuzumab
• Classification: Recombinant Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% ProClin 300
• Gene Accession No.: P16871
• Host Species: Human
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 3575
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: ELISA, Flow Cytometry, Functional Assay, Inhibition Assays, Western Blot, Immunocytochemistry
• Clone: Matuzumab
• Conjugate: Unconjugated
• Gene: Il7r
• Gene Alias: EMD-72000; H425
• Immunogen: Domain III of the extracellular domain of human EGRF.
• Quantity: 200 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1 κ