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Invitrogen™ MAVS Monoclonal Antibody (ABM28H9), PE-Cyanine7, eBioscience™, Invitrogen™
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Catalog No. 25983542
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25-983-542 100 Tests
25-983-541 25 Tests
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Catalog No. 25-983-542 Supplier Invitrogen™ Supplier No. 25983542
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Description

Mouse Monoclonal Antibody

This ABM28H9 MAb recognizes human MAVS, a mitochondrial membrane protein also known as VISA, CARDIF or IPS-1.

Two distinct signaling pathways activate the host innate immunity against viral infection. One pathway is reliant on members of the Toll-like receptor (TLR) family while the other uses the RNA helicase RIG-I as a receptor for intracellular viral double-stranded RNA as a trigger for the immune response. MAVS is a mitochondrial membrane protein that was identified as a critical component in the IFN beta signaling pathways that recruits IRF-3 to RIG-I, leading to its activation and that of NF-kappa-B. MAVS is also thought to interact with other components of the innate immune pathway such as the TLR adapter protein TRIF, TRAF2 and TRAF6. MAVS also interacts with the IKK-alpha, IKK-beta and IKK-iota kinases through its C-terminal region. Cleavage of this region by the Hepatitis C virus (HCV) protease allows HCV to escape the host immune system. Multiple isoforms of MAVS are known to exist.
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Specifications

Antigen MAVS
Applications Flow Cytometry
Classification Monoclonal
Clone ABM28H9
Concentration 5 μL/Test
Conjugate PE-Cyanine7
Formulation PBS with BSA and 0.09% sodium azide; pH 7.2
Gene MAVS
Gene Accession No. Q7Z434
Gene Alias CARD adapter inducing interferon beta; CARD adaptor inducing IFN-beta; Cardif; D430028G21Rik; IFN-B promoter stimulator 1; IFN-beta promoter stimulator-1; interferon beta promoter stimulator protein 1; interferon-beta promoter stimulator protein 1; IPS1; IPS-1; KIAA1271; MAVS; mitochondrial antiviral signaling protein; mitochondrial anti-viral signaling protein; mitochondrial antiviral-signaling protein; Putative NF-kappa-B-activating protein 031N; virus-induced signaling adapter; virus-induced signaling adaptor; virus-induced-signaling adapter; VISA
Gene Symbols MAVS
Host Species Mouse
Immunogen Recombinant fragment of human MAVS (aa 72-296).
Purification Method Affinity chromatography
Quantity 100 Tests
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 57506
Target Species Human
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Isotype IgG2b κ
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