MAVS Mouse anti-Human, Clone: OTI9C7, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF808252

Catalog No. 50-166-8725

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

Two distinct signaling pathways activate the host innate immunity against viral infection. One pathway is reliant on members of the Toll-like receptor (TLR) family while the other uses the RNA helicase RIG-I as a receptor for intracellular viral double-stranded RNA as a trigger for the immune response. VISA is a mitochondrial membrane protein that was identified as a critical component in the IFN-b signaling pathways that recruits IRF-3 to RIG-I, leading to its activation and that of NF-kappa-B. VISA is also thought to interact with other components of the innate immune pathway such as the TLR adapter protein TRIF, TRAF2 and TRAF6. VISA also interacts with the IKK-a, IKK-b and IKK-iota kinases through its C-terminal region. Cleavage of this region by the Hepatitis C virus (HCV) protease allows HCV to escape the host immune system. At least three isoforms of VISA are known to exist.

Specifications

• Antigen: MAVS
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: MAVS
• Gene Alias: CARDIF, IPS-1, IPS1, VISA
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 57506
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Western Blot
• Clone: OTI9C7
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: Q7Z434
• Gene Symbols: MAVS
• Immunogen: Human recombit protein fragment corresponding to amino acids 1-247 of human MAVS produced in E.coli.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG3