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MAVS Recombinant Rabbit Monoclonal Antibody (PSH0-30), Invitrogen™

Catalog No. FEMA550801
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FEMA550801 100 μL
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Catalog No. FEMA550801 Supplier Thermo Scientific Supplier No. MA550801

Description

Rabbit Recombinant Monoclonal Antibody

Positive control: MCF7 cell lysate, C2C12 cell lysate, human colon tissue, human endometrium tissue, A431 cell. Predicted band size: 56 kDa Subcellular Location: Membrane, Mitochondrion, Mitochondrion outer membrane, Peroxisome.

Two distinct signaling pathways activate the host innate immunity against viral infection. One pathway is reliant on members of the Toll-like receptor (TLR) family while the other uses the RNA helicase RIG-I as a receptor for intracellular viral double-stranded RNA as a trigger for the immune response. MAVS is a mitochondrial membrane protein that was identified as a critical component in the IFN beta signaling pathways that recruits IRF-3 to RIG-I, leading to its activation and that of NF-kappa-B. MAVS is also thought to interact with other components of the innate immune pathway such as the TLR adapter protein TRIF, TRAF2 and TRAF6. MAVS also interacts with the IKK-alpha, IKK-beta and IKK-iota kinases through its C-terminal region. Cleavage of this region by the Hepatitis C virus (HCV) protease allows HCV to escape the host immune system. Multiple isoforms of MAVS are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MAVS
Applications Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Classification Recombinant Monoclonal
Clone PSH0-30
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
Gene MAVS
Gene Accession No. Q66HG9, Q7Z434, Q8VCF0
Gene Alias CARD adapter inducing interferon beta, CARD adaptor inducing IFN-beta, Cardif, D430028G21Rik, IFN-B promoter stimulator 1, IFN-beta promoter stimulator-1, interferon beta promoter stimulator protein 1, interferon-beta promoter stimulator protein 1, IPS1, IPS-1, KIAA1271, MAVS, mitochondrial antiviral signaling protein, mitochondrial anti-viral signaling protein, mitochondrial antiviral-signaling protein, Putative NF-kappa-B-activating protein 031N, virus-induced signaling adapter, virus-induced signaling adaptor, virus-induced-signaling adapter, VISA
Gene Symbols MAVS
Host Species Rabbit
Immunogen Synthetic peptide within human MAVS aa 2-50/540.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 228607, 311430, 57506
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form Liquid
Isotype IgG
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